COEXISTENT URTICARIA PIGMENTOSA, ACROMEGALY AND ACANTHOSIS NIGRICANS

被引：6

作者：

AKIYAMA, M

SASAKI, Y

TAKAHASHI, S

HAYAKAWA, K

SUZUKI, H

NISHIKAWA, T

机构：

[1] KEIO UNIV, SCH MED,DEPT DERMATOL,SHINANOMACHI 35,SHINJUKU KU, TOKYO 160, JAPAN

[2] KEIO UNIV, SCH MED, DEPT INTERNAL MED, TOKYO 160, JAPAN

来源：

DERMATOLOGICA | 1991年 / 182卷 / 01期

关键词：

URTICARIA PIGMENTOSA; ACROMEGALY; ACANTHOSIS NIGRICANS; MAST CELLS; GROWTH HORMONE;

D O I：

10.1159/000247738

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a case of urticaria pigmentosa, acromegaly and acanthosis nigricans in a 25-year-old male. The patient exhibited multiple pigmented papules on the trunk and the extremities. Histological examinations of the papules revealed infiltrates of mast cells in the upper dermis. Ultrastructurally, the mast cells were fully matured and exhibited no atypical features. A typical appearance of acromegaly, frontal bossing, prominence of the jaw and bony overgrowth and cutaneous changes of acanthosis nigricans on the neck, the axillae and the groins were observed. Growth hormone hypersecretion and insulin resistance were detected in the patient. A pituitary tumor was found and resected surgically. After the operation, endocrinological abnormalities and cutaneous manifestations of acanthosis nigricans improved markedly. As far as we know, this is the first report of the coexistence of urticaria pigmentosa, acromegaly and acanthosis nigricans.

引用

页码：52 / 55

页数：4

共 24 条

[1] DERMAL CHANGES IN OSTEOPOROSIS FOLLOWING PROLONGED TREATMENT WITH HUMAN GROWTH-HORMONE [J].