INTEGRATED EQUATION TO EVALUATE ACCUMULATION PROFILES OF DRUGS ELIMINATED BY MICHAELIS-MENTEN KINETICS

被引：16

作者：

LAM, G

CHIOU, WL

机构：

[1] UNIV ILLINOIS,MED CTR,COLL PHARM,CLIN PHARMACOKINET LAB,CHICAGO,IL 60612

[2] UNIV ILLINOIS,MED CTR,COLL PHARM,DEPT PHARM,CHICAGO,IL 60612

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1979年 / 7卷 / 02期

关键词：

drug accumulation; Michaelis-Menten kinetics; phenytoin; steady-state concentrations; zero-order input;

D O I：

10.1007/BF01059740

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed. © 1979 Plenum Publishing Corporation.

引用

页码：227 / 232

页数：6

共 15 条

[1] ATKINSON AJ, 1973, CLIN PHARMACOL THER, V14, P521
[2] GARRETTSON LK, 1975, CLIN PHARMACOL THER, V17, P481
[3] ACUTE INTOXICATION WITH 5,5-DIPHENYLHYDANTOIN (DILANTIN) ASSOCIATED WITH IMPAIRMENT OF BIOTRANSFORMATION - PLASMA LEVELS AND URINARY METABOLITES - STUDIES IN HEALTHY VOLUNTEERS
GERBER, N
LYNN, R
OATES, J
[J]. ANNALS OF INTERNAL MEDICINE, 1972, 77 (05) : 765 - +
[4] GUGLER R, 1976, CLIN PHARMACOL THER, V19, P135
[5] KOSTENBAUDER HB, 1975, CLIN PHARMACOL THER, V18, P449
[6] SALICYLATE ACCUMULATION KINETICS IN MAN
LEVY, G
TSUCHIYA, T
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1972, 287 (09) : 430 - &
[7] NOVEL METHOD OF ESTIMATING VOLUME OF DISTRIBUTION OF A DRUG OBEYING MICHAELIS-MENTEN ELIMINATION KINETICS
LIN, YJ
WEIDLER, DJ
GARG, DC
WAGNER, JG
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1978, 6 (03): : 197 - 207
[8] LUDDEN TM, 1976, LANCET, V1, P307
[9] CLINICAL PHARMACOKINETICS OF PHENYTOIN
MARTIN, E
TOZER, TN
SHEINER, LB
RIEGELMAN, S
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1977, 5 (06): : 579 - 596
[10] MULLEN PW, 1978, CLIN PHARMACOL THER, V23, P228

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