(+)-CC-1065 DNA ALKYLATION - OBSERVATION OF AN UNEXPECTED RELATIONSHIP BETWEEN CYCLOPROPANE ELECTROPHILE REACTIVITY AND THE INTENSITY OF DNA ALKYLATION

被引：68

作者：

BOGER, DL

MUNK, SA

ISHIZAKI, T

机构：

[1] Department of Chemistry, Purdue University, West Lafayette

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 07期

关键词：

D O I：

10.1021/ja00007a077

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：2779 / 2780

页数：2

共 17 条

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[2] DEMONSTRATION OF A PRONOUNCED EFFECT OF NONCOVALENT BINDING SELECTIVITY ON THE (+)-CC-1065 DNA ALKYLATION AND IDENTIFICATION OF THE PHARMACOPHORE OF THE ALKYLATION SUBUNIT
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[3] A DEMONSTRATION OF THE INTRINSIC IMPORTANCE OF STABILIZING HYDROPHOBIC BINDING AND NONCOVALENT VANDERWAALS CONTACTS DOMINANT IN THE NONCOVALENT CC-1065/B-DNA BINDING
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[4] TOTAL SYNTHESIS OF (+)-CPI-CDPI2 AND (-)-CPI-CDPI2 - (+)-(3BR,4AS)-DEOXY-CC-1065 AND (-)-(3BS,4AR)-DEOXY-CC-1065
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[5] SYNTHESIS OF N-(TERT-BUTYLOXYCARBONYL)-CBI, CBI, CBI-CDPI1, AND CBI-CDPI2 - ENHANCED FUNCTIONAL ANALOGS OF CC-1065 INCORPORATING THE 1,2,9,9A-TETRAHYDROCYCLOPROPA[C]BENZ[E]INDOL-4-ONE (CBI) LEFT-HAND SUBUNIT
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[6] RESOLUTION OF A CBI PRECURSOR AND INCORPORATION INTO THE SYNTHESIS OF (+)-CBI, (+)-CBI-CDPI1, (+)-CBI-CDPI2 - ENHANCED FUNCTIONAL ANALOGS OF (+)-CC-1065 - A CRITICAL-APPRAISAL OF A PROPOSED RELATIONSHIP BETWEEN ELECTROPHILE REACTIVITY, DNA-BINDING PROPERTIES, AND CYTOTOXIC POTENCY
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[J]. TETRAHEDRON LETTERS, 1990, 31 (06) : 793 - 796
[7] SYNTHESIS AND EVALUATION OF ABORTED AND EXTENDED CC-1065 FUNCTIONAL ANALOGS - (+)-CPI-PDE-I1, AND (-)-CPI-PDE-I1, (+)-CPI-PDE-I1, AND (-)-CPI-CDPI1, AND (+/-)-CPI-PDE-I1, (+)-CPI-PDE-I1, AND (-)-CPI-CDPI3 - PREPARATION OF KEY PARTIAL STRUCTURES AND DEFINITION OF AN ADDITIONAL FUNCTIONAL-ROLE OF THE CC-1065 CENTRAL AND RIGHT-HAND SUBUNITS
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COLEMAN, RS
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[8] SYNTHESIS OF N-(PHENYLSULFONYL)-CI, N-((TERT-BUTYLOXY)CARBONYL)-CI, CI-CDPI1, AND CI-CDPI2 - CC-1065 FUNCTIONAL ANALOGS INCORPORATING THE PARENT 1,2,7,7A-TETRAHYDROCYCLOPROP[1,2-C]INDOL-4-ONE (CI) LEFT-HAND SUBUNIT
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (13) : 5230 - 5240
[9] TOTAL SYNTHESIS AND EVALUATION OF (+/-)-N-(TERT-BUTYLOXYCARBONYL)-CBI, (+/-)-CBI-CDPI1, AND (+/-)-CBI-CDPI2 - CC-1065 FUNCTIONAL AGENTS INCORPORATING THE EQUIVALENT 1,2,9,9A-TETRAHYDROCYCLOPROP[1,2-C]BENZ[1,2-E]INDOL-4-ONE (CBI) LEFT-HAND SUBUNIT
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MUNK, SA
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (16) : 6461 - 6463
[10] TOTAL SYNTHESIS OF (+/-)-N-(PHENYLSULFONYL)-CI AND (+/-)-N-(TERT-BUTYLOXYCARBONYL)-CI, (+/-)-CI-CDPI1, AND (+/-)-CI-CDPI2 - CC-1065 FUNCTIONAL ANALOGS INCORPORATING THE PARENT 1,2,7,7A-TETRAHYDROCYCLOPROP[1,2-C]INDOL-4-ONE (CI) LEFT-HAND SUBUNIT
BOGER, DL
WYSOCKI, RJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (06) : 1238 - 1240

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