CUTANEOUS RESPONSES TO VASOACTIVE INTESTINAL POLYPEPTIDE IN CHRONIC IDIOPATHIC URTICARIA

被引：39

作者：

SMITH, CH

ATKINSON, B

MORRIS, RW

HAYES, N

FOREMAN, JC

LEE, TH

机构：

[1] GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON SE1 9RT,ENGLAND

[2] GUYS HOSP,DEPT PUBL HLTH MED,LONDON SE1 9RT,ENGLAND

[3] UNIV LONDON UNIV COLL,DEPT PHARMACOL,LONDON WC1E 6BT,ENGLAND

来源：

LANCET | 1992年 / 339卷 / 8785期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(92)91000-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cutaneous wheal and flare responses to increasing concentrations of calcitonin gene-related peptide, substance P, neurokinin A, vasoactive intestinal polypeptide (VIP), compound 48/80, and phosphate-buffered saline were measured in 10 patients with chronic idiopathic urticaria and 10 healthy controls. A significant increase in VIP-induced wheal, but not flare or cutaneous blood flow, was seen in urticarial patients compared with controls (p < 0.001). No significant differences in responses to other tested compounds were found between these groups. These data point to an increased sensitivity of microvasculature to VIP in patients with chronic idiopathic urticaria.

引用

页码：91 / 93

页数：3

共 10 条

[1] TOPICAL CAPSAICIN PRETREATMENT INHIBITS AXON REFLEX VASODILATATION CAUSED BY SOMATOSTATIN AND VASOACTIVE INTESTINAL POLYPEPTIDE IN HUMAN-SKIN [J].