DETECTION OF VARICELLA-ZOSTER VIRUS-DNA BY POLYMERASE CHAIN-REACTION IN CEREBROSPINAL-FLUID OF PATIENTS WITH HERPES-ZOSTER MENINGITIS

被引：28

作者：

SHOJI, H ^{[1
]}

HONDA, Y ^{[1
]}

MURAI, I ^{[1
]}

SATO, Y ^{[1
]}

OIZUMI, K ^{[1
]}

HONDO, R ^{[1
]}

机构：

[1] INST PUBL HLTH,DEPT MICROBIOL,TOKYO 108,JAPAN

来源：

JOURNAL OF NEUROLOGY | 1992年 / 239卷 / 02期

关键词：

VARICELLA-ZOSTER VIRUS; DNA GENOME; POLYMERASE CHAIN REACTION; HERPES ZOSTER MENINGITIS;

D O I：

10.1007/BF00862974

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In three of five patients with herpes zoster meningitis, varicella-zoster virus (VZV) DNA was detected by the polymerase chain reaction (PCR) in the initial samples of cerebrospinal fluid. DNA fragments of group A or B, following classification of VZV strains by the size of the variable region IV of VZV genome, were found at the 7th, 10th and 24th illness day in the three positive cases: one of these cases did not have skin lesions. These results suggest that the detection of VZV DNA by PCR is useful for the diagnosis of herpes zoster meningitis, as well as for its molecular epidemiology.

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页码：69 / 70

页数：2

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