CHRONOPHARMACOLOGY OF MELATONIN - INHIBITION BY BENZODIAZEPINE ANTAGONISM

被引：42

作者：

GOLOMBEK, DA

ESCOLAR, E

BURIN, LJ

DE BRITO SANCHEZ, MG

DUQUE, DF

CARDINALI, DP

机构：

[1] Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires

来源：

CHRONOBIOLOGY INTERNATIONAL | 1992年 / 9卷 / 02期

关键词：

MELATONIN; LOCOMOTOR ACTIVITY; ANALGESIA; CONVULSIONS; TIME-DEPENDENT EFFECTS; BENZODIAZEPINE ANTAGONISM;

D O I：

10.3109/07420529209064523

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We endeavored to determine whether three behavioral effects of melatonin in rodents, i.e., depression of locomotor activity in hamsters, analgesia in mice, and impairment of 3-mercaptopropionic acid (3-MP) convulsions, exhibited the time dependency known to occur for several neuroendocrine effects of the hormone. Activity was monitored and registered by means of an optical actometer, and analgesia was assessed by the hot-plate procedure. Locomotor activity, analgesia, and seizure susceptibility were maximal at the beginning of the scotophase and minimal at noon. The effects of melatonin on the three parameters peaked at early night. The administration of the benzodiazepine antagonist flumazenil, although unable by itself to modify locomotor activity, pain, or seizure threshold, blunted the activity of melatonin. These results suggest that the time-dependent effects of melatonin on specific rodent behaviors may be mediated by central synapses employing gamma-aminobutyric acid (GABA) as an inhibitory transmitter.

引用

页码：124 / 131

页数：8

共 32 条

[1] Cardinali D.P., Melatonin. A mammalian pineal hormone, Endocr Rev, 2, pp. 327-346, (1981)
[2] Tamarkin L., Vurtis B., Almeida O.F.X., Melatonin: a coordinating signal for mammalian reproduction, Science, 27, pp. 714-720, (1985)
[3] Reiter R.J., The melatonin message: duration versus coincidence hypotheses, Life Sci, 40, pp. 2119-2131, (1987)
[4] Pevet P., Environmental control of the annual reproductive cycle in mammals. Role of the pineal gland, Comp Physiol Environm Adapt, 3, pp. 82-100, (1987)
[5] Barchas J., DaCosta F., Spector S., Acute pharmacology of melatonin, Nature, 214, pp. 919-920, (1967)
[6] Sugden D., Psychopharmacological effects of melatonin in mouse and rat, J Pharmacol Exp Ther, 227, pp. 587-591, (1983)
[7] Mirmiran M., Pevet P., Effects of melatonin and 5-methoxytryptamine on sleep-wake patterns in the male rat, J Pineal Res, 3, pp. 135-141, (1986)
[8] Vollrath L., Semm P., Gammel G., Sleep induction by intranasal application of melatonin, Melatonin: current status and perspectives, pp. 327-329, (1981)
[9] Lakin M.L., Miller C.H., Stott M.L., Winters W.D., Involvement of the pineal gland and melatonin in murine analgesia, Life Sci, 29, pp. 2543-2551, (1981)
[10] Armstrong S.M., Redman J., Melatonin administration: effects on rodent rhythms, Photoperiodism, melatonin and the pineal, Ciba Foundation Symposium 117, pp. 188-207, (1985)

← 1 2 3 4 →