REDUCED INCREASE IN PLASMA-RENIN ACTIVITY ON WATER-DEPRIVATION IN BLIND HEREDITARY MICROPHTHALMIC RATS

被引：9

作者：

NAGAI, K ^{[1
]}

STOYNEV, AG ^{[1
]}

NAGAI, N ^{[1
]}

NAKAGAWA, H ^{[1
]}

机构：

[1] TRANSPORT MED INST, PHYSIOL LAB, SOFIA, BULGARIA

来源：

NEUROSCIENCE LETTERS | 1993年 / 149卷 / 02期

关键词：

HYPOVOLEMIA; HEMATOCRIT; SUPRACHIASMATIC NUCLEUS; WATER BALANCE; HOMEOSTASIS;

D O I：

10.1016/0304-3940(93)90775-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the plasma renin activity (PRA) before and after 24-h water-deprivation in blind hereditary microphthalmic rats and Donryu rats. In the congenitally blind rats with a morphologically abnormal suprachiasmatic nucleus (SCN), hypovolemia induced significantly less elevation of the PRA and significantly more increase in the hematocrit value than in normal rats. The changes after water-deprivation in the blind rats were quite similar to those reported in rats with SCN lesions. However, the free-running circadian rhythms persisted in these blind rats, whereas those in rats with SCN lesions were completely eliminated. Thus, it is likely that SCN cells are involved in regulation of the PRA, and that if this is the case these cells are different from those containing the circadian pacemaker.

引用

页码：217 / 220

页数：4

共 27 条

[1] GLUTAMATE INJECTION INTO THE SUPRACHIASMATIC NUCLEUS STIMULATES BROWN FAT THERMOGENESIS IN THE RAT [J].