INDUCTION OF HAIR-GROWTH IN EAR WOUNDS BY CULTURED DERMAL PAPILLA CELLS

被引:87
作者
JAHODA, CAB [1 ]
REYNOLDS, AJ [1 ]
OLIVER, RF [1 ]
机构
[1] UNIV DUNDEE,DEPT BIOL SCI,DUNDEE DD1 4HN,SCOTLAND
基金
英国惠康基金;
关键词
HAIR GROWTH; CELL CULTURE; DERMAL PAPILLA; WOUNDS;
D O I
10.1111/1523-1747.ep12366039
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
In the adult hair follicle the dermal papilla plays a crucial role in the dermal-epidermal interactions that control hair production and events of the growth cycle. It has previously been shown that cultured cells from rat vibrissa follicle dermal papillae can stimulate hair growth when implanted into amputated follicles. This study investigated the effects of implanting low-passage cultured papilla cells into small incisional wounds in the rat ear pinna. The groups of fibers that emerged from wound sites were much larger than local hairs, and often had vibrissa-type characteristics. Later-passage papilla cells or cultured skin fibroblasts failed to elicit the same response. Histology revealed that big follicles were formed when papilla cells were trapped between the cut edges of the epidermis. Abnormally large follicles were seen at wound sites many months post-operatively. Independent of epidermal influence, cultured papilla cells in the wound dermis formed rounded papilla-like aggregates that also persisted until biopsy. A previously described method of wrapping papilla cells in glabrous epidermis was less successful in percentage terms but resulted in the production of one very large vibrissa-type follicle and fiber. These results further illustrate that the inductive powers and developmental information retained by cultured dermal papilla cells parallel the properties of their embryonic precursors; the findings may have implications for human hair growth.
引用
收藏
页码:584 / 590
页数:7
相关论文
共 38 条
[1]  
ARAI A, 1989, TRENDS IN HUMAN HAIR GROWTH AND ALOPECIA RESEARCH, P99
[2]  
COHEN J, 1961, J EMBRYOL EXP MORPH, V9, P117
[3]  
COHEN J, 1969, ADVANCES BIOLOGY SKI, V9, P1
[4]   RAT HAIR FOLLICLE DERMAL PAPILLAE HAVE AN EXTRACELLULAR-MATRIX CONTAINING BASEMENT-MEMBRANE COMPONENTS [J].
COUCHMAN, JR .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 87 (06) :762-767
[5]  
DAVIDSON P, 1952, J ANAT, V86, P342
[6]   REGIONAL SPECIFICATION OF CUTANEOUS APPENDAGES IN MAMMALS [J].
DHOUAILLY, D .
WILHELM ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1977, 181 (01) :3-10
[7]   REAPPEARANCE OF AN EMBRYONIC PATTERN OF FIBRONECTIN SPLICING DURING WOUND-HEALING IN THE ADULT-RAT [J].
FFRENCHCONSTANT, C ;
VANDEWATER, L ;
DVORAK, HF ;
HYNES, RO .
JOURNAL OF CELL BIOLOGY, 1989, 109 (02) :903-914
[8]  
HOLBROOK KA, 1991, MOL STRUCTURAL BIOL, V642, P167
[9]  
IBRAHIM L, 1982, J EMBRYOL EXP MORPH, V72, P209
[10]   THE GROWTH OF VIBRISSA DERMAL PAPILLA CELLS-INVITRO [J].
JAHODA, C ;
OLIVER, RF .
BRITISH JOURNAL OF DERMATOLOGY, 1981, 105 (06) :623-627