AUTORADIOGRAPHIC QUANTIFICATION OF MUSCARINIC CHOLINERGIC SYNAPTIC MARKERS IN BAT, SHREW, AND RAT-BRAIN

被引:5
作者
ALBIN, RL
HOWLAND, MM
HIGGINS, DS
FREY, KA
机构
[1] UNIV MICHIGAN HOSP,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109
[4] UNIV MICHIGAN,MENTAL HLTH RES INST,ANN ARBOR,MI 48109
[5] UNIV MICHIGAN,DIV NUCL MED,ANN ARBOR,MI 48109
关键词
VESAMICOL; HEMICHOLINIUM-3; SCOPOLAMINE; MUSCARINIC RECEPTOR; HIGH-AFFINITY CHOLINE UPTAKE; CHOLINERGIC VESICLE;
D O I
10.1007/BF00971334
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of shrew, and the rat. High affinity choline uptake sites were measured with [H-3]hemicholinium, and presynaptic cholinergic vesicles were identified with [H-3]vesamicol. Muscarinic cholinergic receptors were determined with [H-3]scopolamine. The distribution patterns of the three cholinergic markers were similar in all species examined, and identified known major cholinergic pathways on the basis of enrichments in both pre- and postsynaptic markers. In addition, there was excellent agreement, both within and across species, in the regional distributions of the two presynaptic cholinergic markers. Our results indicate that pharmacological identifiers of cholinergic pathways and synapses, including the cholinergic vesicle transport site, and the organizations of central nervous system cholinergic pathways are phylogenetically conserved among eutherian mammals.
引用
收藏
页码:581 / 589
页数:9
相关论文
共 44 条
[1]   [H-3] VESAMICOL BINDING IN BRAIN - AUTORADIOGRAPHIC DISTRIBUTION, PHARMACOLOGY, AND EFFECTS OF CHOLINERGIC LESIONS [J].
ALTAR, CA ;
MARIEN, MR .
SYNAPSE, 1988, 2 (05) :486-493
[2]   DEMONSTRATION OF A RECEPTOR IN TORPEDO SYNAPTIC VESICLES FOR THE ACETYLCHOLINE STORAGE BLOCKER L-TRANS-2-(4-PHENYL[3,4-H-3]-PIPERIDINO)CYCLOHEXANOL [J].
BAHR, BA ;
PARSONS, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (07) :2267-2270
[3]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[4]   CHOLINERGIC NEURONS IN THE TELENCEPHALON OF THE REPTILE CAIMAN-CROCODILUS [J].
BRAUTH, SE ;
KITT, CA ;
PRICE, DL ;
WAINER, BH .
NEUROSCIENCE LETTERS, 1985, 58 (02) :235-240
[5]  
Carroll, 1988, VERTEBRATE PALEONTOL
[6]  
CLARKE PBS, 1985, J NEUROSCI, V5, P1307
[7]   MUSCARINIC CHOLINERGIC RECEPTOR SUBTYPES IN THE RAT-BRAIN .1. QUANTITATIVE AUTORADIOGRAPHIC STUDIES [J].
CORTES, R ;
PALACIOS, JM .
BRAIN RESEARCH, 1986, 362 (02) :227-238
[8]   NEUROTRANSMITTER RECEPTORS IN THE AVIAN BRAIN .2. MUSCARINIC CHOLINERGIC RECEPTORS [J].
DIETL, MM ;
CORTES, R ;
PALACIOS, JM .
BRAIN RESEARCH, 1988, 439 (1-2) :360-365
[9]   HIGH DOSAGE ANTICHOLINERGIC THERAPY IN DYSTONIA [J].
FAHN, S .
NEUROLOGY, 1983, 33 (10) :1255-1261
[10]   THE ORGANIZATION AND SOME PROJECTIONS OF CHOLINERGIC NEURONS OF THE MAMMALIAN FOREBRAIN [J].
FIBIGER, HC .
BRAIN RESEARCH REVIEWS, 1982, 4 (03) :327-388