ACTIVITIES OF POTENTIAL THERAPEUTIC AND PROPHYLACTIC ANTIBIOTICS AGAINST BLOOD CULTURE ISOLATES OF VIRIDANS GROUP STREPTOCOCCI FROM NEUTROPENIC PATIENTS RECEIVING CIPROFLOXACIN

被引：45

作者：

MCWHINNEY, PHM

PATEL, S

WHILEY, RA

HARDIE, JM

GILLESPIE, SH

KIBBLER, CC

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT MICROBIOL,DIV COMMUNICABLE DIS,LONDON NW3 2QG,ENGLAND

[2] UNIV LONDON LONDON HOSP,COLL MED,SCH DENT,DEPT ORAL MICROBIOL,LONDON E1 2AD,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 11期

关键词：

D O I：

10.1128/AAC.37.11.2493

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 mug/ml) and ceftazidime (MIC50, 4 mug/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 mug/ml; those for ciprofloxacin and ofloxacin were >16 and 16 mug/ml, respectively.

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收藏

页码：2493 / 2495

页数：3

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