SYNTHESIS OF THE 5-HT1D RECEPTOR AGONIST MK-0462 VIA A PD-CATALYZED COUPLING REACTION

被引：84

作者：

CHEN, CY ^{[1
]}

LIEBERMAN, DR ^{[1
]}

LARSEN, RD ^{[1
]}

REAMER, RA ^{[1
]}

VERHOEVEN, TR ^{[1
]}

REIDER, PJ ^{[1
]}

COTTRELL, IF ^{[1
]}

HOUGHTON, PG ^{[1
]}

机构：

[1] MERCK RES LABS,DEV LABS,HODDESDON EN11 9BU,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 38期

关键词：

D O I：

10.1016/0040-4039(94)88204-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.

引用

页码：6981 / 6984

页数：4

共 10 条

[1] SYNTHESIS OF 1-ALKYL-1,2,4-TRIAZOLES - A NEW ONE-POT REGIOSPECIFIC PROCEDURE
ASTLEFORD, BA
GOE, GL
KEAY, JG
SCRIVEN, EFV
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (03) : 731 - 732
[2] IMPROVED FISCHER INDOLE REACTION FOR THE PREPARATION OF N,N-DIMETHYLTRYPTAMINES - SYNTHESIS OF L-695,894, A POTENT 5-HT1D RECEPTOR AGONIST
CHEN, CY
SENANAYAKE, CH
BILL, TJ
LARSEN, RD
VERHOEVEN, TR
REIDER, PJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (13) : 3738 - 3741
[3] THE DEVELOPMENT OF A HIGHLY SELECTIVE 5-HT(1) RECEPTOR AGONIST, SUMATRIPTAN, FOR THE TREATMENT OF MIGRAINE
FENIUK, W
HUMPHREY, PPA
[J]. DRUG DEVELOPMENT RESEARCH, 1992, 26 (03) : 235 - 240
[4] MULTIPLE POPULATIONS OF SEROTONIN RECEPTORS MAY MODULATE THE BEHAVIORAL-EFFECTS OF SEROTONERGIC AGENTS
GLENNON, RA
DARMANI, NA
MARTIN, BR
[J]. LIFE SCIENCES, 1991, 48 (26) : 2493 - 2498
[5] HOPKINS S J, 1992, Drugs of Today, V28, P155
[6] HOUGHTON PJ, UNPUB
[7] SYNTHESIS OF INDOLES VIA PALLADIUM-CATALYZED HETEROANNULATION OF INTERNAL ALKYNES
LAROCK, RC
YUM, EK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (17) : 6689 - 6690
[8] SMITH DW, 1993, Patent No. 0548813
[9] PALLADIUM-CATALYZED SYNTHESIS OF HETEROCONDENSED PYRROLES
WENSBO, D
ERIKSSON, A
JESCHKE, T
ANNBY, U
GRONOWITZ, S
COHEN, LA
[J]. TETRAHEDRON LETTERS, 1993, 34 (17) : 2823 - 2826
[10] WENSBO D, 1993, TETRAHEDRON LETT, V34, P6471

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