CHANGES IN GLYCOPROTEINS OF LIVER PLASMA-MEMBRANES FROM RATS TREATED WITH D-GALACTOSAMINE

被引：6

作者：

BERTRAND, F

VEISSIERE, D

PICARD, J

机构：

[1] Laboratoire de biochimie, Faculté de médecine Saint-Antoine, Paris

来源：

DIGESTION | 1979年 / 19卷 / 05期

关键词：

Galactosamine; Gel electrophoresis; Glycoproteins; Hepatitis; Hexosamine; Hexoses; Liver; Plasma membranes; Rats; Sialic acid; Sulfates;

D O I：

10.1159/000198373

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

D-Galactosamine administration to rats (400mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and h after D-galactosamine injection. Plasma membrane 5’-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition was significantly changed. After 24 h D-galactosamine administration, the diminution in plasma membrane sialic acids and hexoses reached 30% of control values. As detected by SDS-acrylamide gel electrophoresis, high molecular weight glycoproteins of D-galactosamine-treated plasma membranes were modified. Moreover, the incorporation of [35S]-sulfate into membrane glycoproteins decreased after D-galactosamine administration (40–60% of control). The present results show that biochemical alterations in rat liver plasma membranes appear soon after D-galactosamine injection. Marked changes are observed in cell surface glycoproteins, especially in sialoglycoproteins and sulfated glycoproteins. © 1979 S. Karger AG, Basel.

引用

页码：284 / 291

页数：8

共 32 条

[1]

ANUKARAHANONTA T, 1973, RES COMMUN CHEM PATH, V5, P481

[2] STUDIES ON RAT-LIVER PLASMA-MEMBRANE - ALTERED PROTEIN AND PHOSPHOLID METABOLISM AFTER INJECTION OF D-GALACTOSAMINE [J].