TISSUE CHARACTERIZATION OF BRAIN-TUMORS DURING AND AFTER PION RADIATION-THERAPY

被引：7

作者：

BOESIGER, P

GREINER, R

SCHOEPFLIN, RE

KANN, R

KUENZI, U

机构：

[1] Institute of Biomedical Engineering and Medical Informatics, University of Zurich

[2] Swiss Federal Institute of Technology (IBTZ)

[3] Paul Scherrer Institute (PSI), Division of Radiation Medicine

来源：

MAGNETIC RESONANCE IMAGING | 1990年 / 8卷 / 04期

关键词：

Brain tumors; Pion radiation therapy monitoring; Radiotherapy monitoring; Tissue characterization;

D O I：

10.1016/0730-725X(90)90057-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Negative Pi-mesons (pions) are applied at the Paul Scherrer Institute in the radiotherapy of highly malignant gliomas using a dose escalation program. The therapy effects of 7 randomly selected patients were followed up by 62 MRI examinations. The quantification of the effects is based on the relaxation times T1 and T2, which are acquired by a new designed multi-echo multiple saturation recovery imaging technique. As a summary of the results, roughly two reaction types are observed. For both types the relaxation times increase up to two to three months after the radiation therapy. Then in one type (two patients) the T1 and T2 values of the tumors, and of the edemas surrounding the tumors, further increase, indicating an unfavorable prognosis. In the other type (five patients) the relaxation times drop down towards, or even below, their initial values, reflecting the onset of the reparation processes in the tissue. This later behaviour reflects an at least temporary control of the disease; that is, the short term prognosis for these patients is more favorable. It further can be concluded, with respect to our MR parameters, that the radiotolerance of healthy brain tissue is much higher than that of malignant glioma tissue, despite the fact that these tumors are very seldom definitively radiosensible. © 1990.

引用

页码：491 / 497

页数：7

共 12 条

[1]

Raju, Pion and Heavy Ion Radiotherapy: Pre-Clinical and Clinical Studies, pp. 269-278, (1983)

[2]

Blattmann, Pedroni, Crawford, Salzmann, Pion and Heavy Ion Radiotherapy: Pre-Clinical and Clinical Studies, pp. 119-128, (1983)

[3]

von Essen, Blattmann, Bodendorfer, Mizoe, Pedroni, Walder, Zimmermann, The piotron: II. Methods and initial results of dynamic therapy in phase II studies, Int. J. Rad. Oncol. Biol. Phys., 11, pp. 217-226, (1985)

[4]

Vescey, The piotron channel at SIN, Pion and Heavy Ion Radiotherapy: Pre-Clinical and Clinical Studies, pp. 23-35, (1982)

[5]

von Essen, Blattmann, Crawford, Fessenden, Pedroni, Perret, Salzmann, Shortt, Walder, The piotron: Initial performance, preparation and experience with piotron therapy, Int. J. Rad. Oncol. Biol. Phys., 8, pp. 1499-1509, (1982)

[6]

Pedroni, Development of the therapy planning programs for the 60 beams SIN pion applicator, Rad. Environm. Biophys., 16, pp. 211-217, (1979)

[7]

Schoepflin, Boesiger, A Multi Echo Multiple Saturation Recovery Sequence for High Accurate Spin Density, T<sub>1</sub> and T<sub>2</sub> Imaging, Seventh Annual Meeting of Society of Magnetic Resonance in Medicine, (1988)

[8]

Greiner, Blattmann, Strahlentherapie mit negativen Pi-Mesonen: Wirkungssteigerung der Strahlentherapie maligner Tumoren, pp. 146-165, (1987)

[9]

Schoepflin, Boesiger, Meier, Critical evaluation of the quality of synthetic MR images, Magn. Reson. Imaging, 4, pp. 435-436, (1986)

[10]

Boesiger, Greiner, Schoepflin, Kann, Kuenzi, Follow Up of Pion Radiation Therapy of Brain Tumors, Seventh Annual Meeting of Society of Magnetic Resonance in Medicine, (1988)

← 1 2 →