METHAMPHETAMINE-INDUCED CHANGES IN BRAIN CATECHOLAMINES IN RATS AND GUINEA-PIGS

被引：105

作者：

WAGNER, GC

SEIDEN, LS

SCHUSTER, CR

机构：

[1] UNIV CHICAGO, DEPT PHARMACOL & PHYSIOL SCI, CHICAGO, IL 60637 USA

[2] UNIV CHICAGO, DEPT PSYCHIAT, CHICAGO, IL 60637 USA

来源：

DRUG AND ALCOHOL DEPENDENCE | 1979年 / 4卷 / 05期

关键词：

D O I：

10.1016/0376-8716(79)90076-0

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Methamphetamine is a commonly abused drug by humans. Repeated administration of methamphetamine caused long-term changes in caudate dopamine levels in the rat and guinea-pig. Methamphetamine was administered twice a day for 30 days. Two wk following the last injection, the animals were killed and brains assayed for catecholamine content. These long-term depletions of dopamine, when combined with similar observations previously reported in rhesus monkeys, indicate a species generality of the effects of methamphetamine on caudate dopamine levels.

引用

页码：435 / 438

页数：4

共 8 条

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