SERINE DERIVED OXAZOLIDINES AS SECONDARY STRUCTURE DISRUPTING, SOLUBILIZING BUILDING-BLOCKS IN PEPTIDE-SYNTHESIS

被引：142

作者：

HAACK, T ^{[1
]}

MUTTER, M ^{[1
]}

机构：

[1] UNIV LAUSANNE,CHIM SECT,RUE BARRE 2,CH-1005 LAUSANNE,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)91681-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The incorporation of serine as oxazolidine protected ''pseudo proline'' in a host peptide results in the disruption of secondary structure formation thus increasing the solvation of the peptide chain. The use of this protection technique for serine, threonine or cysteine represents a powerful tool to modulate the conformational and physico- chemical properties of peptides.

引用

页码：1589 / 1592

页数：4

共 12 条

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