LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY OF PLASMA-GLUCOSE AND SECRETED GLUCURONATE FOR METABOLIC STUDIES IN HUMANS

被引：21

作者：

REID, S

SHACKLETON, C

WU, K

KAEMPFER, S

HELLERSTEIN, MK

机构：

[1] CHILDRENS HOSP,OAKLAND RES INST,CLIN MASS SPECT FACIL,OAKLAND,CA 94609

[2] UNIV CALIF BERKELEY,DEPT NUTR SCI,BERKELEY,CA 94720

[3] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO GEN HOSP,KORET CTR HUMAN NUTR,SAN FRANCISCO,CA

来源：

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY | 1990年 / 19卷 / 09期

关键词：

D O I：

10.1002/bms.1200190903

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Negative ion thermospray liquid chromatographic/mass spectrometric methods have been developed for the determination of isotopic enrichments for glucose and acetaminophen—uridine diphosphate glucuronate from (1‐2H1)glucose, (1‐2H1)galactose and (2‐13C)acetate in humans. The error of estimate ranged from below 1% to 5%. The advantages of the method include fast analysis (up to 35 per hour), eased sample preparation, good precision, sensitivity comparable with gas chromatography/mass spectrometry and better than with isotope ratio mass spectrometry. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：535 / 540

页数：6

共 13 条

[1]

HELLERSTEIN M K, 1989, FASEB Journal, V3, pA244

[2]

HELLERSTEIN MK, 1987, CLIN RES, V35, pA505

[3] GLYCOCONJUGATES AS NONINVASIVE PROBES OF INTRAHEPATIC METABOLISM .3. APPLICATION TO GALACTOSE ASSIMILATION BY THE INTACT RAT [J].