MONOAMINE-OXIDASE INHIBITORS PREVENT STRIATAL NEURONAL NECROSIS INDUCED BY TRANSIENT FOREBRAIN ISCHEMIA

被引：50

作者：

MATSUI, Y ^{[1
]}

KUMAGAE, Y ^{[1
]}

机构：

[1] SANKYO CO LTD,BIOL RES LABS,TOKYO 140,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 02期

关键词：

CEREBRAL ISCHEMIA; DOPAMINE; STRIATUM; MONOAMINE OXIDASE INHIBITOR; NEURONAL NECROSIS;

D O I：

10.1016/0304-3940(91)90547-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Seven days after 30 min of ischemia, neuronal necrosis was observed in the striatum. Pretreatment with type A monoamine oxidase (MAO-A) inhibitors, clorgyline and RS-8359 ((+)-4-(4-cyanoanilino)-7-hydroxycyclopenta(3,2-e) pyrimidine) decreased significantly the number of necrotic neurons and inhibited changes in the dopamine metabolite contents during and after transient ischemia. An MAO-B inhibitor, deprenyl also decreased the neuronal necrosis, but it inhibited only the changes in 3,4-dihydroxyphenylacetic acid (DOPAC) content after reperfusion. The results suggest that the activation of dopamine metabolism after transient ischemia was mainly mediated by MAO-A and partly by MAO-B and suggest a possible role of dopamine deamination by MAO in the development of ischemic neuronal necrosis.

引用

页码：175 / 178

页数：4

共 29 条

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