THE SELECTIVE NK3 RECEPTOR AGONIST SENKTIDE EXCITES A SUBPOPULATION OF DOPAMINE-SENSITIVE NEURONS IN THE RAT SUBSTANTIA-NIGRA PARS COMPACTA INVITRO

被引：50

作者：

KEEGAN, KD

WOODRUFF, GN

PINNOCK, RD

机构：

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 105卷 / 01期

关键词：

BASAL GANGLIA; SUBSTANTIA-NIGRA; DOPAMINE; TACHYKININ; SENKTIDE; NEUROKININ;

D O I：

10.1111/j.1476-5381.1992.tb14199.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intra- and extracellular recordings were made from substantia nigra zona compacta neurones from an in vitro rat brain slice preparation. A subpopulation of dopamine-sensitive neurones were encountered which were potently excited by bath application of the NK3 receptor agonist, senktide. On these senktide-sensitive neurones, NK1 and NK2 receptor agonists were inactive. The excitatory action of senktide supports a role for tachykinins as putative neurotransmitters in the basal ganglia.

引用

页码：3 / 5

页数：3

共 10 条

[1] EFFECT OF IMMUNONEUTRALIZATION OF SUBSTANCE-P IN CAT SUBSTANTIA NIGRA ON RELEASE OF DOPAMINE FROM DENDRITES AND TERMINALS OF DOPAMINERGIC-NEURONS
CHERAMY, A
MICHELOT, R
LEVIEL, V
NIEOULLON, A
GLOWINSKI, J
KERDELHUE, B
[J]. BRAIN RESEARCH, 1978, 155 (02) : 404 - 408
[2] VISUALIZATION OF NEUROKININ-3 RECEPTOR-SITES IN RAT-BRAIN USING THE HIGHLY SELECTIVE LIGAND [H-3] SENKTIDE
DAM, TV
ESCHER, E
QUIRION, R
[J]. BRAIN RESEARCH, 1990, 506 (01) : 175 - 179
[3] THE PHYSIOLOGY AND PHARMACOLOGY OF MAMMALIAN BASAL GANGLIA
DRAY, A
[J]. PROGRESS IN NEUROBIOLOGY, 1980, 14 (04) : 221 - 335
[4] KANAZAWA I, 1984, Neuroscience Research, V2, P111, DOI 10.1016/0168-0102(84)90009-9
[5] KEEGAN KD, 1990, BRIT J PHARMACOL, V101, pP579
[6] DISTRIBUTION OF SUBSTANCE P-LIKE IMMUNOREACTIVITY IN CENTRAL NERVOUS-SYSTEM OF RAT .2. LIGHT MICROSCOPIC LOCALIZATION IN RELATION TO CATECHOLAMINE-CONTAINING NEURONS
LJUNGDAHL, A
HOKFELT, T
NILSSON, G
GOLDSTEIN, M
[J]. NEUROSCIENCE, 1978, 3 (10) : 945 - +
[7] CORRELATION BETWEEN INOSITOL PHOSPHOLIPID HYDROLYSIS AND SUBSTANCE-P RECEPTORS IN RAT CNS
MANTYH, PW
PINNOCK, RD
DOWNES, CP
GOEDERT, M
HUNT, SP
[J]. NATURE, 1984, 309 (5971) : 795 - 797
[8] NEUROTENSIN DEPOLARIZES SUBSTANTIA NIGRA DOPAMINE NEURONS
PINNOCK, RD
[J]. BRAIN RESEARCH, 1985, 338 (01) : 151 - 154
[9] DIFFERENTIAL SENSITIVITY OF PRESUMED DOPAMINERGIC AND NON-DOPAMINERGIC NEURONS IN RAT SUBSTANTIA NIGRA TO ELECTROPHORETICALLY APPLIED SUBSTANCE-P
PINNOCK, RD
DRAY, A
[J]. NEUROSCIENCE LETTERS, 1982, 29 (02) : 153 - 158
[10] PINNOCK RD, 1983, NEUROSCI LETT S, V14, pS286

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