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EFFECTS OF NIFEDIPINE ON NORMOTENSIVE RAT PLACENTAL BLOOD-FLOW, PLACENTAL WEIGHT AND FETAL WEIGHT

被引：9
作者：
FURUHASHI, N
TSUJIEI, M
KIMURA, H
YAJIMA, A
机构：
[1] Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai
来源：
GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1991年 / 32卷 / 01期
关键词：
NIFEDIPINE; PLACENTAL BLOOD FLOW; PLACENTAL WEIGHT; FETAL WEIGHT; NORMOTENSIVE RAT;
D O I：
10.1159/000292979
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Recently, nifedipine (Ca antagonist) has been used for the treatment of preeclampsia. In this study, we investigated the effects of nifedipine on the normotensive Wistar Kyoto rat's placental blood flow, fetal weight and placental weight. We measured the rat's placental blood flow using clearance of hydrogen gas generated by electrolysis. The placental blood flow, placental and fetal weights of nifedipine-treated rats (5, 10 and 25 mg/kg) were significantly (p < 0.05) reduced compared with normal pregnant rats. These data suggest that nifedipine might have some reducing effects on placental blood flow, fetal weight and placental weight.
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页码：1 / 3
页数：3
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