ZINC MEDIATED ADDITION OF ACTIVE HALIDES TO A GLYCINE CATION EQUIVALENT - SYNTHESIS OF N-BOC-L-PROPARGYLGLYCINE

被引：11

作者：

ABOOD, NA

NOSAL, R

机构：

[1] Department of Chemistry Searle Research and Development, Skokie

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)73067-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of allylic, benzylic and propargylic halides with zinc in the presence of the glycine cation equivalent, methyl N-Boc-2-acetoxyglycine, affords Boc protected amino acid derivatives in high yield. Resolution of methyl N-Boc-propargylglycine with alpha-chymotrypsin affords N-Boc-L-propargylglycine in 99% e.e..

引用

页码：3669 / 3672

页数：4

共 16 条

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