MAPPING THE FLV LOCUS CONTROLLING RESISTANCE TO FLAVIVIRUSES ON MOUSE CHROMOSOME-5

被引：40

作者：

SANGSTER, MY ^{[1
]}

UROSEVIC, N ^{[1
]}

MANSFIELD, JP ^{[1
]}

MACKENZIE, JS ^{[1
]}

SHELLAM, GR ^{[1
]}

机构：

[1] UNIV WESTERN AUSTRALIA,QUEEN ELIZABETH II MED CTR,DEPT MICROBIOL,NEDLANDS,WA 6009,AUSTRALIA

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 01期

关键词：

D O I：

10.1128/JVI.68.1.448-452.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetically determined resistance to flaviviruses in mice is a dominant trait conferred by alleles at a single autosomal locus designated Flv, but no gene products have been associated with this locus and the mechanism of resistance is not well understood. To further characterize this model of genetic resistance, we conducted mapping studies to determine the chromosomal location of Flv. Because of evidence suggesting that the Flv locus is on chromosome 5, three-point backcross linkage analyses were used to define the location of Flv relative to previously assigned chromosome 5 markers. The results confirm the chromosome 5 location of Flv and indicate a map position between the anchor loci rd and Gus-s. The chromosomal localization of Flv is the first step in the production of a detailed linkage map of the Flv region, which may open approaches to positional cloning of the resistance gene.

引用

页码：448 / 452

页数：5

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