EFFECTS OF MALIGNANCY AND INTERLEUKIN-2 INFUSION ON GUT MACROMOLECULAR PERMEABILITY

Objective: Enhanced gut permeability has been shown in patients with advanced malignancy, The dramatic inflammatory shock syndrome produced by high-dose interleukin-a immune therapy could further change gut barrier function, This study measured the effect of advanced renal cell carcinoma and malignant melanoma, and interleukin-2 treatment on gut permeability, Design: Nonrandomized, controlled study, Setting: University hospital, Patients: Adults with metastatic, unresectable renal cell carcinoma or metastatic, malignant melanoma, and normal volunteers, Interventions: Gut permeability was measured in patients with renal cell carcinoma or malignant melanoma before and during interleukin-a infusions, using polyethylene glycol 3350 and polyethylene glycol 400. The polyethylene glycols were administered orally within 48 hrs of interleukin-a therapy and the 24-hr urine excretions were measured. Measurements and Main Results: Increased permeability was seen in the baseline state of these patients (ratio of polyethylene glycol 3350 to polyethylene glycol 400 = 1.1 +/- 0.7 x 10(-2)) when compared with normal volunteers (ratio = 0.48 +/- 0.2 x 10(-2); p < .05), However, after interleukin-a treatment, no further increase in permeability was seem (ratio = 1.4 +/- 0.8 x 10(-2)). Conclusions: Gut permeability to polyethylene glycol 3350 is enhanced in advanced malignancy. High-dose interleukin-2 therapy does not further increase permeability of the gut.