DELTA-OPIOID PEPTIDE RECEPTORS IN MUSCLES FROM OBESE-DIABETIC AND NORMAL MICE

被引：17

作者：

EVANS, AAL ^{[1
]}

HUGHES, S ^{[1
]}

SMITH, ME ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT PHYSIOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

PEPTIDES | 1995年 / 16卷 / 02期

关键词：

OPIOID RECEPTORS; BETA-ENDORPHIN; SKELETAL MUSCLE; D-ALA(2)]DELTORPHIN-II; DPDPE; TYPE II DIABETES; OB/OB MOUSE;

D O I：

10.1016/0196-9781(94)00185-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoradiography was used to study the opioid receptors in soleus and extensor digitorum longus (EDL) muscles from normal mice and mice with type II diabetes. Binding sites for [I-125]beta-endorphin were present on the surface membranes in muscles from normal mice. The density of receptors was higher in muscles from obese diabetic mice. The specific delta-opioid ligands DPDPE and [D-Ala(2)]deltorphin-II inhibited the binding of [I-125]beta-endorphin whereas mu and kappa agonists did not. Therefore, the opioid receptor present in skeletal muscle fibers of the mouse is of the delta subtype and the number of these receptors is increased in type II diabetes in the mouse.

引用

页码：361 / 364

页数：4

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