FURTHER STUDIES ON INHIBITION OF MONOAMINE OXIDASE BY M AND B 9302 (CLORGYLINE) .I. SUBSTRATE SPECIFICITY IN VARIOUS MAMMALIAN SPECIES

Evidence is presented concerning the nature of the substrate specificity of the monoamine oxidase (MAO) complex from rat liver and brain, utilising a nonhydrazine inhibitor, M & B 9302. The binary nature of the MAO complex is discussed in the light of the results. MAO from various mammalian species has been examined. It was possible to demonstrate the presence of two MAO enzymes from the brains of rat, man, rabbit, ox, dog and cat and from the livers of rat and man. The MAO from the brain of the pig and the livers of all species examined other than rat and man, appeared, from the evidence, to be homogeneous. © 1969.