EVIDENCE FOR AN ESSENTIAL LYSINE RESIDUE ON THE PHOSPHORIBOSYL TRANSFERASE SUBUNIT OF THE ANTHRANILATE SYNTHETASE-ANTHRANILATE 5-PHOSPHORIBOSYL-PYROPHOSPHATE PHOSPHORIBOSYLTRANSFERASE ENZYME COMPLEX FROM SALMONELLA-TYPHIMURIUM

被引：5

作者：

GROVE, TH ^{[1
]}

LEVY, HR ^{[1
]}

机构：

[1] SYRACUSE UNIV,DEPT BIOL,BIOL RES LABS,SYRACUSE,NY 13210

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)90877-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyridoxal 5′-phosphate reacts with the anthranilate synthetase-phosphoribosyltransferase enzyme complex of Salmonella typhimurium to inhibit PR transferase activity. Glutamine-dependent anthranilate synthetase is not affected. Spectral and kinetic data suggest that the inactivation results from the modification of an essential lysine residue which interacts with 5-phosphoribosyl 1-pyrophosphate. © 1979.

引用

页码：387 / 394

页数：8

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