THE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF A CDNA-ENCODING A NEW SPECIES OF PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN (PSBETA-G)

被引：3

作者：

ARAKAWA, F

KUROKI, M

MISUMI, Y

MATSUO, Y

MATSUOKA, Y

机构：

[1] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM 1,7-45-1 NANAKUMA,FUKUOKA 81401,JAPAN

[2] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM 2,FUKUOKA 81401,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1048卷 / 2-3期

关键词：

(Human placenta); Carcinoembryonic antigen gene family; cDNA cloning; β[!sub]1[!/sub]-Glycoprotein; pregnancy specific;

D O I：

10.1016/0167-4781(90)90072-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We screened a cDNA library of a human placenta with cDNA for nonspecific cross-reacting antigen, a member of the carcinoembryonic antigen gene family. One of the positive clones, PS34, was found to encode a 426 amino acid protein belonging to pregnancy-specific β1-glycoprotein (PSβG). The mature PS34 protein consisted of domains, N, A1, A2, B2 and C. The domain-N of PS34 showed sequence similarities of 79.8-83.5% to those of the PSβG members so far reported, indicating PS34 is a new member of PSβG and also of the carcinoembryonic antigen gene family. © 1990.

引用

收藏

页码：303 / 305

页数：3

相关论文

共 15 条

[1] MOLECULAR-CLONING AND EXPRESSION OF CDNA FOR A CARCINOEMBRYONIC ANTIGEN-RELATED FETAL LIVER GLYCOPROTEIN [J].

KHAN, WN ;

OSTERMAN, A ;

HAMMARSTROM, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3332-3336

[2] CARCINOEMBRYONIC ANTIGEN GENE FAMILY - MOLECULAR-CLONING OF CDNA FOR A PS-BETA-G/FL-NCA GLYCOPROTEIN WITH A NOVEL DOMAIN ARRANGEMENT [J].

KHAN, WN ;

HAMMARSTROM, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :525-535

[3] PRIMARY STRUCTURE OF RAT-LIVER ALKALINE-PHOSPHATASE DEDUCED FROM ITS CDNA [J].

MISUMI, Y ;

TASHIRO, K ;

HATTORI, M ;

SAKAKI, Y ;

IKEHARA, Y .

BIOCHEMICAL JOURNAL, 1988, 249 (03) :661-668

[4] EXON-INTRON ORGANIZATION OF A GENE FOR PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN, A SUBFAMILY MEMBER OF CEA FAMILY - IMPLICATIONS FOR ITS CHARACTERISTIC REPETITIVE DOMAINS AND C-TERMINAL SEQUENCES [J].

OIKAWA, S ;

INUZUKA, C ;

KOSAKI, G ;

NAKAZATO, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 156 (01) :68-77

[5] THE CARCINOEMBRYONIC ANTIGEN (CEA) CONTAINS MULTIPLE IMMUNOGLOBULIN-LIKE DOMAINS [J].

OIKAWA, S ;

IMAJO, S ;

NOGUCHI, T ;

KOSAKI, G ;

NAKAZATO, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 144 (02) :634-642

[6] A PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN, A CEA GENE FAMILY MEMBER, EXPRESSED IN A HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE, HL-60 - STRUCTURES OF PROTEIN, MESSENGER-RNA AND GENE [J].

OIKAWA, S ;

INUZUKA, C ;

KUROKI, M ;

MATSUOKA, Y ;

KOSAKI, G ;

NAKAZATO, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) :1021-1031

[7] SEQUENCE-ANALYSIS OF CARCINOEMBRYONIC ANTIGEN - IDENTIFICATION OF GLYCOSYLATION SITES AND HOMOLOGY WITH THE IMMUNOGLOBULIN SUPERGENE FAMILY [J].

PAXTON, RJ ;

MOOSER, G ;

PANDE, H ;

LEE, TD ;

SHIVELY, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (04) :920-924

[8] MOLECULAR-CLONING OF A CDNA FOR HUMAN PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN - HOMOLOGY WITH HUMAN CARCINOEMBRYONIC ANTIGEN AND RELATED PROTEINS [J].

ROONEY, BC ;

HORNE, CHW ;

HARDMAN, N .

GENE, 1988, 71 (02) :439-449

[9] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].

SANGER, F ;

NICKLEN, S ;

COULSON, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467

[10] THE HUMAN PREGNANCY-SPECIFIC-BETA-1-GLYCOPROTEIN (PS-BETA-G) AND THE CARCINOEMBRYONIC ANTIGEN (CEA)-RELATED PROTEINS ARE MEMBERS OF THE SAME MULTIGENE FAMILY [J].

STREYDIO, C ;

LACKA, K ;

SWILLENS, S ;

VASSART, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (01) :130-137