QUANTITATIVE-ANALYSIS OF GLUTATHIONE IN RAT CENTRAL-NERVOUS-SYSTEM - COMPARISON OF GSH IN INFANT BRAIN WITH THAT IN ADULT BRAIN

被引：30

作者：

KUDO, H

KOKUNAI, T

KONDOH, T

TAMAKI, N

MATSUMOTO, S

机构：

[1] Department of Neurosurgery, Kobe University School of Medicine, Kobe

来源：

BRAIN RESEARCH | 1990年 / 511卷 / 02期

关键词：

Adult brain; Free radical; Glutathione; Infant brain;

D O I：

10.1016/0006-8993(90)90178-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reduced glutathione (GSH) plays an important role in cellular protection against damage from free radicals and other electrophiles. GSH in the rat central nervous system was quantitatively analyzed. In adult brain, tissue from the cerebellum had higher GSH levels than that from the brainstem and spinal cord. Infant cerebrum and cerebellum contained lower levels of GSH than adult cerebrum and cerebellum. These data seem to suggest that the brainstem and spinal cord in adults, and the cerebrum and cerebellum in infants, are more vulnerable to injury by free radical-like radiation than the cerebrum and cerebellum in adults. © 1990.

引用

页码：326 / 328

页数：3

共 19 条

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