DUODENAL SP-LIKE IMMUNOREACTIVITY IS DECREASED IN EXPERIMENTALLY-INDUCED DUODENAL-ULCERS

被引：4

作者：

EVANGELISTA, S ^{[1
]}

RENZI, D ^{[1
]}

MANTELLINI, P ^{[1
]}

SURRENTI, C ^{[1
]}

MELI, A ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT ANIM GENET,GASTROENTEROL UNIT,I-50121 FLORENCE,ITALY

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

Cysteamine; Dulcerozine; Duodenal ulcer; Mepirizole; Substance P-like immunoreactivity;

D O I：

10.1016/0304-3940(90)90230-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced duodenal lesions is inversely correlated with the levels of duodenal SP-li. A significant decrease in duodenal SP-li was observed at 24 h, but not at 6 h after a single oral dose of cysteamine. These findings show that endogenous SP may play an importal local role in duodenal ulcerogenesis. © 1990.

引用

页码：352 / 355

页数：4

共 14 条

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