CONCENTRATION OF CHOLECYSTOKININ IN CEREBROSPINAL-FLUID IS DECREASED IN PSYCHOSIS - RELATIONSHIP TO SYMPTOMS AND DRUG RESPONSE

被引：28

作者：

BEINFELD, MC

GARVER, DL

机构：

[1] ST LOUIS UNIV,SCH MED,DEPT PHARMACOL,ST LOUIS,MO 63104

[2] UNIV ALABAMA,DEPT PSYCHIAT & BEHAV NEUROBIOL,BIRMINGHAM,AL 35294

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1991年 / 15卷 / 05期

关键词：

ANTIPSYCHOTIC RESPONSE; CEREBROSPINAL FLUID CHOLECYSTOKININ; HALOPERIDOL; SCHIZOPHRENIA;

D O I：

10.1016/0278-5846(91)90050-B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Cholecystokinin (CCK) is a neuropeptide which is co-localized within some mesolimbic and mesocortical dopamine neurons. 2. CCK resembles an antipsychotic drug in some pharmacological and behavioral tests. 3. Levels of CCK in the cerebrospinal fluid (CSF) are reduced in eleven drug-free schizophrenics in comparison with six controls. 4. Schizophrenic males have lower CSF CCK levels than females. 5. Rapidity of antipsychotic response to haloperidol appeared to be inversely related to drug-free baseline CSF CCK levels.

引用

页码：601 / 609

页数：9

共 34 条

[1] THE DISTRIBUTION OF CHOLECYSTOKININ IMMUNOREACTIVITY IN THE CENTRAL NERVOUS-SYSTEM OF THE RAT AS DETERMINED BY RADIOIMMUNOASSAY [J].