CYCLOSPORINE-A PROTECTS AGAINST ISCHEMIA-REPERFUSION INJURY IN THE BRAIN

被引：164

作者：

SHIGA, Y

ONODERA, H

MATSUO, Y

KOGURE, K

机构：

[1] Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai

来源：

BRAIN RESEARCH | 1992年 / 595卷 / 01期

关键词：

TRANSIENT FOCAL BRAIN ISCHEMIA; CEREBRAL INFARCTION; BRAIN EDEMA; CYCLOSPORINE-A;

D O I：

10.1016/0006-8993(92)91465-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion injury in the brain using a transient focal ischemia model in rats. In CsA-treated rats, ischemic brain edema formation 1 day after reperfusion in the cerebral cortex perfused by the middle cerebral artery (MCA) and infarct size were decreased compared with those in olive oil treated control rats. These results suggest that CsA is beneficial in reducing ischemia-reperfusion injury, possibly by the suppression of immunological reactions.

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页码：145 / 148

页数：4

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