INTRAORGANELLAR LOCALIZATION OF COASH-INDEPENDENT PHYTANIC ACID OXIDATION IN HUMAN LIVER PEROXISOMES

被引：22

作者：

PAHAN, K ^{[1
]}

SINGH, I ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,DEPT PEDIAT,171 ASHLEY AVE,CHARLESTON,SC 29425

来源：

FEBS LETTERS | 1993年 / 333卷 / 1-2期

关键词：

PEROXISOME; PHYTANIC ACID; PHYTANOYL-COA LIGASE; PHYTANIC ACID ALPHA-OXIDATION;

D O I：

10.1016/0014-5793(93)80395-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In human tissues phytanic acid is alpha-oxidized to pristanic acid in peroxisomes. Studies of the intraorganellar site of alpha-oxidation of [1-C-14]phytanic acid to pristanic acid in peroxisomes isolated from human liver demonstrate that phytanoyl-CoA ligase is present in the peroxisomal membrane and that the enzyme system for alpha-oxidation of phytanic acid to pristanic acid is in the peroxisomal matrix. In contrast to the beta-oxidation system for fatty acids, the substrate for alpha-oxidation is free phytanic acid. The studies described in this manuscript report a novel fatty acid oxidation system where the substrate for the enzyme system is free fatty acid; however, phytanoyl-CoA ligase regulates the alpha-oxidation of phytanic acid at the organellar (peroxisomal) level.

引用

页码：154 / 158

页数：5

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