EFFECTS OF MITOCHONDRIA CONCENTRATION AND AGE, ENERGY AND INHIBITORS OF MITOCHONDRIAL ANION TRANSPORT ON MALATE TRANSPORT IN ISOLATED RAT-HEART MITOCHONDRIA

被引：5

作者：

BARRITT, GJ

机构：

[1] Clinical Biochemistry Unit, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1978年 / 9卷 / 05期

关键词：

D O I：

10.1016/0020-711X(78)90104-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. The rate and extent of exchange of external [14C]malate with endogenous counter ions in isolated rat heart mitochondria was found to depend markedly on the concentration and age of the isolated mitochondria. 2. 2. Ascorbic acid plus tetramethylphenylenediamine, or ATP stimulated malate exchange at low concentrations of mitochondria (0.2-0.8 mg protein per ml) but caused inhibition at higher concentrations. 3. 3. The rate of malate exchange was partially inhibited by atractyloside and benzene- 1,2,3-tricarboxylate, completely inhibited by 2-phenylsuccinate, 2-benzylmalonate and high concentrations of mersalyl, and stimulated by N-ethylmaleimide. © 1978.

引用

页码：317 / 322

页数：6

共 23 条

[1]

BRIERLEY GP, 1974, RECENT ADV STUDIES C, V4, P1

[2] PHOSPHATE TRANSPORT IN RAT-LIVER MITOCHONDRIA - KINETICS, INHIBITOR SENSITIVITY, ENERGY-REQUIREMENTS, AND LABELED COMPONENTS [J].