CUPRIC ION-CATALYZED HYDROLYSIS OF PENICILLINS - MECHANISM AND SITE OF COMPLEXATION

被引：54

作者：

CRESSMAN, WA

SUGITA, ET

DOLUISIO, JT

NIEBERGALL, PJ

机构：

[1] Department of Pliarmacy, The Philadelphia College of Pliarmncy and Science, Philadelphia, Pennsylvania

[2] University of Kentucky, College of Pharmacy, Lexington, Kentucky

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 12期

关键词：

Hydrolysis; penicillin—mechanism; site of complexation; Ionic strength effect—penicillin degradation; IR spectrophotometry—identification; Penicillin hydrolysis—cupric ion‐catalyzed; pH effect—penicillin degradation; Temperature effect—penicillin degradation; UV spectrophotometry—identification;

D O I：

10.1002/jps.2600581210

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The presence of Cu(II) in penicillin solutions, through the pH range 4.0–6.0, has been shown previously to promote the degradation of the penicillins studied to their corresponding penicilloic acids. This study was undertaken to further substantiate the reaction mechanism and to postulate the catalytic site of complexation of Cu(II) with penicillin. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1471 / +

页数：1

共 20 条

[1]

Bronsted JN, 1922, Z PHYS CHEM-STOCH VE, V102, P169

[2] 6-CHLORO- AND 6-BROMOPENICILLANIC ACIDS [J].