INHIBITORY EFFECTS OF 2'-FLUORINATED ARABINOSYL-PYRIMIDINE NUCLEOSIDES ON WOODCHUCK HEPATITIS-VIRUS REPLICATION IN CHRONICALLY INFECTED WOODCHUCKS

被引：53

作者：

FOUREL, I

HANTZ, O

WATANABE, KA

JACQUET, C

CHOMEL, B

FOX, JJ

TREPO, C

机构：

[1] INSERM,U271,UNITE RECH HEPATITES SIDA & RETROVIRUS HUMAINS,151 COURS A THOMAS,F-69424 LYONS,FRANCE

[2] ECOLE NATL VET,F-69280 MARCY LETOILE,FRANCE

[3] MEM SLOAN KETTERING CANC CTR,ORGAN CHEM LAB,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 03期

关键词：

D O I：

10.1128/AAC.34.3.473

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.

引用

页码：473 / 475

页数：3

共 18 条

[1] SERUM ALPHA-FETOPROTEIN LEVELS IN HUMAN-DISEASE - PERSPECTIVE FROM A HIGHLY SPECIFIC MONOCLONAL RADIOIMMUNOASSAY
BELLET, DH
WANDS, JR
ISSELBACHER, KJ
BOHUON, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (12): : 3869 - 3873
[2] COMPARATIVE-STUDY OF DHBV DNA LEVELS AND ENDOGENOUS DNA-POLYMERASE ACTIVITY IN NATURALLY INFECTED DUCKLINGS IN FRANCE
COVA, L
HANTZ, O
ARLIAUDGASSIN, M
CHEVALIER, A
BERTHILLON, P
BOULAY, J
JACQUET, C
CHOMEL, B
VITVITSKI, L
TREPO, C
[J]. JOURNAL OF VIROLOGICAL METHODS, 1985, 10 (03) : 251 - 260
[3] PILOT-STUDY OF RECOMBINANT HUMAN ALPHA-INTERFERON FOR CHRONIC TYPE-B HEPATITIS
DOOLEY, JS
DAVIS, GL
PETERS, M
WAGGONER, JG
GOODMAN, Z
HOOFNAGLE, JH
[J]. GASTROENTEROLOGY, 1986, 90 (01) : 150 - 157
[4] Fox J. J., 1987, FLUORINATED CARBOXYD, P176
[5] FROMMEL D, 1984, AM J PATHOL, V115, P125
[6] NUCLEOTIDE-SEQUENCE OF A CLONED WOODCHUCK HEPATITIS-VIRUS GENOME - COMPARISON WITH THE HEPATITIS-B VIRUS SEQUENCE
GALIBERT, F
CHEN, TN
MANDART, E
[J]. JOURNAL OF VIROLOGY, 1982, 41 (01) : 51 - 65
[7] THE MOLECULAR-BIOLOGY OF THE HEPATITIS-B VIRUSES
GANEM, D
VARMUS, HE
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 : 651 - 693
[8] GUST ID, 1986, INTERVIROLOGY, V25, P14, DOI 10.1159/000149651
[9] INHIBITION OF HUMAN AND WOODCHUCK HEPATITIS-VIRUS DNA-POLYMERASE BY THE TRIPHOSPHATES OF ACYCLOVIR, 1-(2'-DEOXY-2'-FLUORO-BETA-D-ARABINOFURANOSYL)-5-IODOCYTOSINE AND E-5-(2-BROMOVINYL)-2'-DEOXYURIDINE
HANTZ, O
ALLAUDEEN, HS
OOKA, T
DECLERCQ, E
TREPO, C
[J]. ANTIVIRAL RESEARCH, 1984, 4 (04) : 187 - 199
[10] EFFECTS OF ADENINE-ARABINOSIDE ON SERUM AND INTRAHEPATIC REPLICATIVE FORMS OF DUCK HEPATITIS-B VIRUS IN CHRONIC INFECTION
HIROTA, K
SHERKER, AH
OMATA, M
YOKOSUKA, O
OKUDA, K
[J]. HEPATOLOGY, 1987, 7 (01) : 24 - 28

← 1 2 →