GLYCOSYLATION WITH SIALIC-ACID AT HO-3 OF 3 DIFFERENT O-PROTECTED D-GALACTOSIDES IN ACETONITRILE DICHLOROMETHANE AT LOW-TEMPERATURE

被引：23

作者：

BIRBERG, W

LONN, H

机构：

[1] LUND INST TECHNOL,CTR CHEM,S-22100 LUND,SWEDEN

[2] BIOCARB TECHNOL AB,S-22370 LUND,SWEDEN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 50期

关键词：

SIALIC ACID; GLYCOSYLATION; DIFFERENT ACCEPTORS; ALPHA-SELECTIVITY; LOW TEMPERATURE;

D O I：

10.1016/0040-4039(91)80133-Q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three different O-protected D-galactosides have been compared as acceptors in alpha-sialoside synthesis using glycosyl donor 1, methylsulfenyl triflate as promoter, and acetonitrile/dichloromethane as solvent at - 70-degrees-C. The 6-O-benzylated acceptor 2 was the most efficient, the alpha(2-3) sialoside 5 was obtained in 39% isolated yield.

引用

页码：7457 / 7458

页数：2

共 8 条

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