GLYCOSYLATION WITH SIALIC-ACID AT HO-3 OF 3 DIFFERENT O-PROTECTED D-GALACTOSIDES IN ACETONITRILE DICHLOROMETHANE AT LOW-TEMPERATURE

被引:23
作者
BIRBERG, W
LONN, H
机构
[1] LUND INST TECHNOL,CTR CHEM,S-22100 LUND,SWEDEN
[2] BIOCARB TECHNOL AB,S-22370 LUND,SWEDEN
关键词
SIALIC ACID; GLYCOSYLATION; DIFFERENT ACCEPTORS; ALPHA-SELECTIVITY; LOW TEMPERATURE;
D O I
10.1016/0040-4039(91)80133-Q
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three different O-protected D-galactosides have been compared as acceptors in alpha-sialoside synthesis using glycosyl donor 1, methylsulfenyl triflate as promoter, and acetonitrile/dichloromethane as solvent at - 70-degrees-C. The 6-O-benzylated acceptor 2 was the most efficient, the alpha(2-3) sialoside 5 was obtained in 39% isolated yield.
引用
收藏
页码:7457 / 7458
页数:2
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