REGULATION OF RIBOSOMAL-PROTEIN S25 IN HL-60 CELLS ISOLATED FOR RESISTANCE TO ADRIAMYCIN

被引：13

作者：

LI, ML ^{[1
]}

CENTER, MS ^{[1
]}

机构：

[1] KANSAS STATE UNIV AGR & APPL SCI,DIV BIOL,MANHATTAN,KS 66506

来源：

FEBS LETTERS | 1992年 / 298卷 / 2-3期

关键词：

RIBOSOMAL PROTEIN S25; GENE OVEREXPRESSION; ADRIAMYCIN; DRUG-RESISTANCE;

D O I：

10.1016/0014-5793(92)80041-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ribosomal protein S25 gene is highly overexpressed in HL60 cells isolated for resistance to adriamycin. In contrast there is no overexpression of 3 other ribosomal genes which code for proteins S14, S17 and S24. Studies with an antibody against a synthetic peptide of the S25 protein show that although the S25 gene is overexpressed in resistant cells there is no corresponding increase in the levels of S25 protein. These results suggest that the r-protein levels are highly regulated by translational controls or protein turnover.

引用

页码：142 / 144

页数：3

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