A COCAINE ANALOG AND A GBR ANALOG LABEL THE SAME PROTEIN IN RAT STRIATAL MEMBRANES

被引：20

作者：

PATEL, A

BOJA, JW

LEVER, J

LEW, R

SIMANTOV, R

CARROLL, FI

LEWIN, AH

PHILIP, A

GAO, YG

KUHAR, MJ

机构：

[1] NIDA,ADDICT RES CTR,NEUROSCI BRANCH,POB 5180,BALTIMORE,MD 21224

[2] JOHNS HOPKINS UNIV,BALTIMORE,MD 21205

[3] RES TRIANGLE INST,RES TRIANGLE PK,NC 27709

来源：

BRAIN RESEARCH | 1992年 / 576卷 / 01期

关键词：

COCAINE; DOPAMINE UPTAKE; DOPAMINE TRANSPORTER; PHOTOAFFINITY LABELING; DEEP;

D O I：

10.1016/0006-8993(92)90627-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Because some evidence suggests that cocaine and GBR12935 bind to different sites, we utilized photoaffinity probes from both classes of compounds to see if they label the same protein. [I-125]RTI-82 a cocaine analog, and [I-125]DEEP, a GBR analog, labeled protein(s) showing the same molecular weight, a similar pharmacological profile and a similar sensitivity to neuraminidase.

引用

收藏

页码：173 / 174

页数：2

相关论文

共 12 条

[1] COMPLEX INTERACTION OF COCAINE WITH THE DOPAMINE UPTAKE CARRIER [J].

BERGER, P ;

ELSWORTH, JD ;

REITH, MEA ;

TANEN, D ;

ROTH, RH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 176 (02) :251-252

[2]

BERGER SP, 1991, MOL PHARMACOL, V39, P429

[3]

GRIGORIADIS DE, 1989, J NEUROSCI, V9, P2664

[4] CLONING AND EXPRESSION OF A RAT-BRAIN GABA TRANSPORTER [J].

GUASTELLA, J ;

NELSON, N ;

NELSON, H ;

CZYZYK, L ;

KEYNAN, S ;

MIEDEL, MC ;

DAVIDSON, N ;

LESTER, HA ;

KANNER, BI .

SCIENCE, 1990, 249 (4974) :1303-1306

[5] CLONING AND EXPRESSION OF A COCAINE-SENSITIVE RAT DOPAMINE TRANSPORTER [J].

KILTY, JE ;

LORANG, D ;

AMARA, SG .

SCIENCE, 1991, 254 (5031) :578-579

[6] DOPAMINE TRANSPORTERS IN THE NUCLEUS-ACCUMBENS AND THE STRIATUM HAVE DIFFERENT APPARENT MOLECULAR-WEIGHTS [J].

LEW, R ;

VAUGHAN, R ;

SIMANTOV, R ;

WILSON, A ;

KUHAR, MJ .

SYNAPSE, 1991, 8 (02) :152-153

[7] DOPAMINE TRANSPORTER - DEGLYCOSYLATION WITH EXOGLYCOSIDASES AND ENDOGLYCOSIDASES [J].

LEW, R ;

GRIGORIADIS, D ;

WILSON, A ;

BOJA, JW ;

SIMANTOV, R ;

KUHAR, MJ .

BRAIN RESEARCH, 1991, 539 (02) :239-246

[8]

MADRAS BK, 1989, MOL PHARMACOL, V36, P518

[9] EXPRESSION CLONING OF A COCAINE-SENSITIVE AND ANTIDEPRESSANT-SENSITIVE HUMAN NORADRENALINE TRANSPORTER [J].

PACHOLCZYK, T ;

BLAKELY, RD ;

AMARA, SG .

NATURE, 1991, 350 (6316) :350-354

[10] PHOTOAFFINITY-LABELING OF THE MAMMALIAN DOPAMINE TRANSPORTER [J].

SALLEE, FR ;

FOGEL, EL ;

SCHWARTZ, E ;

CHOI, SM ;

CURRAN, DP ;

NIZNIK, HB .

FEBS LETTERS, 1989, 256 (1-2) :219-224