Analysis of circulating microRNAs during adjuvant chemotherapy in patients with luminal A breast cancer

被引：18

作者：

Yoruker, Ebru Esin ^{[1
]}

Aydogan, Fatma ^{[2
]}

Gezer, Ugur ^{[1
]}

Saip, Pinar ^{[2
]}

Dalay, Nejat ^{[1
]}

机构：

[1] Istanbul Univ, Dept Basic Oncol, Inst Oncol, TR-34093 Istanbul, Turkey

[2] Istanbul Univ, Inst Oncol, Dept Clin Oncol, TR-34093 Istanbul, Turkey

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2015年 / 3卷 / 04期

关键词：

breast cancer; circulating microRNAs; serum samples;

D O I：

10.3892/mco.2015.567

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is a complex disease displaying different profiles involving genetic as well as epigenetic factors. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression. Recent studies demonstrated that miRNAs may display great potential for the development of novel biomarkers and therapeutic targets. In the present study, the levels of miR-21 and miR-145 were analyzed in the peripheral blood of 52 patients with luminal A breast cancer. miRNA expression was determined in serum samples from matched pre- and post-treatment patients with breast cancer by quantitative polymerase chain reaction. There were no statistically significant differences in miR-145 and miR-21 levels between pre- and post-treatment samples. In addition, the miRNA levels were not found to be associated with the clinical parameters.

引用

页码：954 / 958

页数：5

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