PHENOTYPIC PROFILE AND FUNCTIONAL-CHARACTERISTICS OF HUMAN GAMMA AND DELTA T-CELLS DURING ACUTE TOXOPLASMOSIS

被引：42

作者：

DEPAOLI, P

BASAGLIA, G

GENNARI, D

CROVATTO, M

MODOLO, ML

SANTINI, G

机构：

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1992年 / 30卷 / 03期

关键词：

D O I：

10.1128/JCM.30.3.729-731.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gamma and delta (gamma-delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma-delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma-delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma-delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.

引用

页码：729 / 731

页数：3

共 18 条

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