BIOCHEMICAL CORROBORATION OF ENDOTHELIAL INVOLVEMENT IN SEVERE PREECLAMPSIA

被引：124

作者：

FRIEDMAN, SA

SCHIFF, E

EMEIS, JJ

DEKKER, GA

SIBAI, BM

机构：

[1] TNO,PG,GAUBIUS LAB,LEIDEN,NETHERLANDS

[2] FREE UNIV AMSTERDAM HOSP,DEPT OBSTET & GYNECOL,AMSTERDAM,NETHERLANDS

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1995年 / 172卷 / 01期

关键词：

PREECLAMPSIA; ENDOTHELIUM; CELLULAR FIBRONECTIN; VON WILLEBRAND FACTOR; TISSUE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR-1;

D O I：

10.1016/0002-9378(95)90113-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This prospective, nested, case-control study investigated whether elevated plasma cellular fibronectin concentrations previously reported in preeclamptic women likely reflect endothelial dysfunction. In addition to higher maternal plasma concentrations of cellular fibronectin, we found higher levels of von Willebrand factor, tissue plasminogen activator, and plasminogen activator inhibitor-1 in maternal plasma, providing biochemical corroboration of endothelial dysfunction in severe preeclampsia.

引用

页码：202 / 203

页数：2