SYNTHESIS OF A CHEMICALLY AND METABOLICALLY STABLE AND BIOLOGICALLY POTENT PGD2-ANALOG

被引：6

作者：

BUCHMANN, B

SKUBALLA, W

VORBRUGGEN, H

机构：

[1] Research Laboratories, Schering AG

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)97413-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The metabolic labile α-chain of the PGD2-annlogue 2 (ZK 110841) can be stabilized by introduction of an β-oxygen-atom resulting in 3 (ZK 118182), which has a much higher and longer lasting biological activity on oral application in rats. The synthetic methodology for the synthesis of 3-oxaZ-Δ5,6-prostaglandins will be discussed. © 1990.

引用

页码：3425 / 3428

页数：4

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