3-AMINO-2-ARYLPROPANOIC ACIDS BY ELECTROPHILIC SUBSTITUTION OF 2-ARYLETHYLAMINES AT THE BENZYLIC POSITION

被引：9

作者：

SIMIG, G ^{[1
]}

SCHLOSSER, M ^{[1
]}

机构：

[1] UNIV LAUSANNE,INST CHIM ORGAN,RUE BARRE 2,CH-1005 LAUSANNE,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 17期

关键词：

D O I：

10.1016/0040-4039(91)85013-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reaction sequence consisting of N-pivaloylation, lithiation at the benzylic position, carboxylation and deprotection allows to convert 2-arylethylamines into 3-amino-2-arylpropanoic acids with good yields.

引用

页码：1963 / 1964

页数：2

共 11 条

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[6]

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[7] ORTHO-SELECTIVE METALATION AND ELECTROPHILIC SUBSTITUTION OF BENZYLAMINE DERIVATIVES [J].

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TETRAHEDRON LETTERS, 1988, 29 (34) :4277-4280

[8] DIRECTED METALATION REACTIONS .6. COMPETITION OF SUBSTITUENTS FOR ORTHO DIRECTION OF METALATION IN SUBSTITUTED ANISOLES [J].

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JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (23) :3653-3664

[9] COMPARATIVE BEHAVIOUR UPON LITHIATION OF DIMETHYLAMINOETHYLFERROCENE AND BETA-PHENETHYLDIMETHYLAMINE [J].

SLOCUM, DW ;

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JENNINGS, CA .

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[10]

SLOCUM DW, 1970, TETRAHEDRON LETT, V11, P3443

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