RADARIN-A, RADARIN-B, RADARIN-C, AND RADARIN-D - NEW ANTIINSECTAN AND CYTOTOXIC INDOLE DITERPENOIDS FROM THE SCLEROTIA OF ASPERGILLUS-SULPHUREUS

被引:20
作者
LAAKSO, JA
GLOER, JB
WICKLOW, DT
DOWD, PF
机构
[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242
[2] USDA ARS,CTR AGR UTILIZAT RES,PEORIA,IL 61604
关键词
D O I
10.1021/jo00027a026
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Four new indole diterpenoids, radarins A-D (3-6), have been isolated from the sclerotia of Aspergillus sulphureus by chromatographic separation of the CH2Cl2 extract. The structure of radarin A (3) was determined using extensive high-field 2D NMR experiments. Radarins B-D (4-6) were assigned by analysis of NMR data, spectral comparison to 3, and/or by chemical interconversion. Compound 3 has the most potent activity against the corn earworm Helicoverpa zea and exhibits significant cytotoxicity in assays against three human solid tumor cell lines.
引用
收藏
页码:138 / 141
页数:4
相关论文
共 18 条