THE RESPONSE OF RAT-LIVER LIPID-PEROXIDATION, ANTIOXIDANT ENZYME-ACTIVITIES AND GLUTATHIONE CONCENTRATION TO THE THYROID-HORMONE

被引：52

作者：

MORINI, P ^{[1
]}

CASALINO, E ^{[1
]}

SBLANO, C ^{[1
]}

LANDRISCINA, C ^{[1
]}

机构：

[1] UNIV BARI, FAC VET MED, BIOCHEM LAB, VIA GENTILE 182, I-70126 BARI, ITALY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1991年 / 23卷 / 10期

关键词：

D O I：

10.1016/0020-711X(91)90140-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. In liver microsomes from hyperthyroid rats NADPH-dependent lipid peroxidation induces a hydroperoxide formation 56% higher than that in euthyroid ones. 2. The addition of 5-mu-M Fe2+ (or Fe3+) strongly decreases the hydroperoxide level in favour of that of TBA-reactive substances. Higher iron concentrations (30-mu-M) have no significant effect. 3. In hepatocytes from hyperthyroid rats CCl4-induced lipid peroxidation produces an amount of TBA-reactive substances four times higher than that in those from euthyroid rats. 4. In the liver of hyperthyroid rats a GSH concentration decrease (by about 35%) is found while the opposite occurs in the blood of the same animals where GSH increases 2.5 times. 5. It is shown that in the liver of hyperthyroid rats, besides higher lipid peroxidation, a more active defence mechanism is operating since both glutathione peroxidase and glutathione reductase specific activities are higher than in euthyroid rats.

引用

页码：1025 / 1030

页数：6

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