IMPROVED SURVIVAL IN A REPLANTATION MODEL CONTAINING ISCHEMIC MUSCLE

被引：17

作者：

CONCANNON, MJ ^{[1
]}

DOOLEY, TW ^{[1
]}

PUCKETT, CL ^{[1
]}

机构：

[1] UNIV MISSOURI,HLTH SCI CTR,DIV PLAST & RECONSTRUCT SURG,ONE HOSP DR,COLUMBIA,MO 65212

来源：

MICROSURGERY | 1991年 / 12卷 / 01期

关键词：

D O I：

10.1002/micr.1920120105

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The effectiveness of superoxide dismutase and allopurinol was evaluated in preventing reperfusion injury in Sprague‐Dawley rats utilizing a limb replantation model after 6 hours of warm ischemia. Immediately prior to reperfusion of the replanted limb the animals received (intravenously) either a single bolus of superoxide dismutase (16,000 units/kg), a single bolus of allopurinol (45 mg/kg), both agents, or only control solutions. In the rats that received only control solutions, 30% of the limbs survived the ischemic insult. The group that received both superoxide dismutase and allopurinol had a 75% limb survival (P = 0.005). The animals that had only superoxide dismutase or allopurinol had 58% and 60% of the replanted limbs survive, respectively. This study suggests that the administration of superoxide dismutase and allopurinol may be helpful in the prevention of reperfusion injury in skeletal muscle in an acute injury setting (without pretreatment) and may thereby improve limb salvage after a significant ischemic period. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：18 / 22

页数：5

共 34 条

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