LOSS OF Y-CHROMOSOME IN GASTRIC-CARCINOMA - FACT OR ARTIFACT

被引：20

作者：

CASTEDO, S

CORREIA, C

GOMES, P

SERUCA, R

SOARES, P

CARNEIRO, F

SOBRINHOSIMOES, M

机构：

[1] UNIV PORTO,DEPT MED GENET,OPORTO,PORTUGAL

[2] UNIV PORTO,DEPT PATHOL,OPORTO,PORTUGAL

[3] PORTUGUESE INST ONCOL,DEPT GENET,OPORTO,PORTUGAL

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 61卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90367-H

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Loss of chromosome Y has been reported in gastric cancer cells together with other chromosomal abnormalities. We noted loss of chromosome Y and near-diploid karyotypes in five cases of gastric adenocarcinoma, but DNA flow cytometry performed on fresh tumor tissue showed aneuploid peaks in four of them. Our findings suggest that loss of the Y chromosome in gastric cancer probably reflects the karyotype of a subpopulation of stromal cells and not a neoplasia-related chromosomal aberration.

引用

页码：39 / 41

页数：3

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