SEQUENCING OF CYCLODEPSIPEPTIDES (DESTRUXINS) USING POSITIVE FAST-ATOM-BOMBARDMENT DESORPTION TANDEM MASS-SPECTROMETRY

被引：14

作者：

LANGE, C

MULHEIM, C

VEY, A

PAIS, M

机构：

[1] CNRS,INRA,PATHOL COMPAREE STN,URA 11840,F-30380 ST CHRISTOL ALES,FRANCE

[2] CNRS 92,INST CHIM SUBSTANCES NAT,GIF SUR YVETTE,FRANCE

来源：

BIOLOGICAL MASS SPECTROMETRY | 1992年 / 21卷 / 01期

关键词：

D O I：

10.1002/bms.1200210108

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The development of fast atom bombardment tandem mass spectrometry methodology is applied to the sequencing of the destruxin toxins (cyclodepsipeptides) which are 'wrong' cyclopeptides. The strategy is discussed in detail. Possible ways to overcome problems related to the resolution of isobaric fragment ions using deuterated compounds and the distinction between sequence and retrosequence are examined.

引用

页码：33 / 42

页数：10

共 46 条

[1]

ALEXANDER AJ, 1989, RAPID COMMUN MASS SP, V3, P30

[2] STRUCTURE DETERMINATION OF A CYCLIC TETRAPEPTIDE - TENTOXINE BY MASS-SPECTROMETRY USING FAST ATOM BOMBARDMENT FOR IONIZATION [J].