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MEASUREMENT OF BRAIN PERFUSION BY VOLUME-LOCALIZED NMR-SPECTROSCOPY USING INVERSION OF ARTERIAL WATER SPINS - ACCOUNTING FOR TRANSIT-TIME AND CROSS-RELAXATION

被引：98
作者：
ZHANG, WG
WILLIAMS, DS
DETRE, JA
KORETSKY, AP
机构：
[1] CARNEGIE MELLON UNIV,DEPT BIOL SCI,PITTSBURGH,PA 15213
[2] UNIV PENN,SCH MED,DEPT NEUROL,PHILADELPHIA,PA 19104
来源：
MAGNETIC RESONANCE IN MEDICINE | 1992年 / 25卷 / 02期
关键词：
D O I：
10.1002/mrm.1910250216
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The theoretical model for perfusion measurement by NMR using arterial labeling of endogenous water is extended to include the effects of transit time and cross‐relaxation of tissue water with macromolecules. Water magnetization in rat brain is monitored using the STEAM method to simultaneously determine the transit time, magnetization transfer rate constant, and perfusion. The results show that the transit time in rat brain is quite short, and thus its effect on perfusion measurement is small. It is also demonstrated both theoretically and experimentally that the steady‐state effects of cross‐relaxation with macromolecules on perfusion measurement are accounted for by a proper control experiment. © 1992 Academic Press, Inc. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
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页码：362 / 371
页数：10
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