CHANGES IN DOPA DECARBOXYLASE MESSENGER-RNA BUT NOT TYROSINE-HYDROXYLASE MESSENGER-RNA LEVELS IN RAT-BRAIN FOLLOWING ANTIPSYCHOTIC TREATMENT

被引:39
作者
BUCKLAND, PR
ODONOVAN, MC
MCGUFFIN, P
机构
[1] Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, CF4 4XN, Heath Park
关键词
ANTIPSYCHOTICS; SCHIZOPHRENIA; DOPA DECARBOXYLASE; TYROSINE HYDROXYLASE; MESSENGER RNA LEVELS;
D O I
10.1007/BF02245292
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of antipsychotic administration (1-32 days, twice per day) on the levels of mRNA coding for dopa decarboxylase (DDC) and tyrosine hydroxylase (TH) in rat brain has been assessed by a procedure utilising solution hybridisation with oligonucleotides. Saline and sulpiride (20 mg/kg/day) had no apparent effect on DDC mRNA levels. Haloperidol (3 mg/kg/day) elicited increases in DDC mRNA levels of 240% after 32 days and loxapine (4 mg/kg/day) elicited increases of 180% in DDC mRNA levels. None of the drugs affected TH mRNA levels. These results indicate that DDC may be more important than TH in the long term regulation of dopamine production.
引用
收藏
页码:98 / 102
页数:5
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