A NEGATIVE ASSOCIATION OF SCHIZOPHRENIA WITH AN ALLELE OF THE HLA-DQB1 GENE AMONG AFRICAN-AMERICANS

被引:21
作者
NIMGAONKAR, VL
GANGULI, R
RUDERT, WA
VAVASSORI, C
RABIN, BS
TRUCCO, M
机构
[1] UNIV PITTSBURGH,SCH MED,DEPT PSYCHIAT,PITTSBURGH,PA 15208
[2] UNIV PITTSBURGH,SCH MED,DEPT PEDIAT,PITTSBURGH,PA 15208
[3] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15208
关键词
GENETICS; ASSOCIATION; HLA; HLA DQB; AUTOIMMUNE; DIABETES-MELLITUS; (SCHIZOPHRENIA);
D O I
10.1016/0920-9964(93)90018-E
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Using polymorphisms of the human leukocyte antigen (HLA) DQB1 gene, a case-control study was conducted in a group of patients with schizophrenia (DSM-III, n = 58) and psychiatrically normal controls matched for ethnicity (n = 72), living in the same geographical area. A significant negative association of allele HLA DQB1*0602 with schizophrenia was present among African-Americans (odds ratio 0.19), but could not be detected in Caucasians.
引用
收藏
页码:199 / 209
页数:11
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