A NEGATIVE ASSOCIATION OF SCHIZOPHRENIA WITH AN ALLELE OF THE HLA-DQB1 GENE AMONG AFRICAN-AMERICANS

被引：21

作者：

NIMGAONKAR, VL

GANGULI, R

RUDERT, WA

VAVASSORI, C

RABIN, BS

TRUCCO, M

机构：

[1] UNIV PITTSBURGH,SCH MED,DEPT PSYCHIAT,PITTSBURGH,PA 15208

[2] UNIV PITTSBURGH,SCH MED,DEPT PEDIAT,PITTSBURGH,PA 15208

[3] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15208

来源：

SCHIZOPHRENIA RESEARCH | 1993年 / 8卷 / 03期

关键词：

GENETICS; ASSOCIATION; HLA; HLA DQB; AUTOIMMUNE; DIABETES-MELLITUS; (SCHIZOPHRENIA);

D O I：

10.1016/0920-9964(93)90018-E

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Using polymorphisms of the human leukocyte antigen (HLA) DQB1 gene, a case-control study was conducted in a group of patients with schizophrenia (DSM-III, n = 58) and psychiatrically normal controls matched for ethnicity (n = 72), living in the same geographical area. A significant negative association of allele HLA DQB1*0602 with schizophrenia was present among African-Americans (odds ratio 0.19), but could not be detected in Caucasians.

引用

页码：199 / 209

页数：11

共 123 条

[1] HLA IN PSYCHIATRIC AND CONTROL SUBJECTS - A COMPARATIVE-STUDY OF HLA-ANTIGEN FREQUENCIES IN SCHIZOPHRENIC, SCHIZOAFFECTIVE AND CONTROL SUBJECTS [J].